Veterans Medical Research Foundation Of Sd
Veterans Medical Research Foundation Of Sd
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About this organization
Mission
Honoring Military Service With Science; Our Bench-To-Bedside Approach Has Led To Breakthroughs In Areas Such As Shingles Prevention, Heart Disease, Metabolic Diseases And Ground Breaking Work On Post-Traumatic Stress Disorder.
About
DR. GUATELLI-ENHANCEMENT OF INFECTIVITY BY HIV-1 VIA ANTAGONISM OF SERINC PROTEINS. THE PURPOSE OF THIS PROJECT IS TO 1) COMBINE OUR BIOCHEMICAL, CELL BIOLOGIC, AND VIROLOGIC ASSAYS TO VALIDATE AND ELABORATE THESE MECHANISMS 2) DETERMINE THE STRUCTURAL BASIS OF SERINC ANTAGONISM BY NEF. WE AIM TO PROVIDE HIGH-RESOLUTION STRUCTURES OF THE INTERACTION OF NEF WITH SERINC PROTEINS AND CLATHRIN ADAPTORS. 3) DETERMINE HOW SERINC PROTEINS AFFECT INFECTIVITY IN AN ENV-DEPENDENT MANNER. TO FACILITATE AN UNDERSTANDING OF SERINC FUNCTION, WE WILL CHARACTERIZE A FULL-LENGTH PROTEIN BIOPHYSICALLY AND AIM TO PROVIDE A HIGH-RESOLUTION STRUCTURE. WE WILL TEST THE HYPOTHESIS THAT SERINC PROTEINS INTERACT WITH ENV TO INHIBIT INFECTIVITY AND MAP THE INTERACTION. WE WILL DETERMINE WHETHER SERINC PROTEINS AFFECT THE CONFORMATION OF ENV TRIMERS AS DISPLAYED ON THE CELL SURFACE AND ON VIRIONS. LASTLY, WE WILL ELABORATE A MODEL IN WHICH THE CYTOPLASMIC DOMAIN OF ENV CONTRIBUTES TO COUNTERACTION OF SERINC PROTEINS. WHEN THE PROPOSED EXPERIMENTS ARE COMPLETE, WE SHOULD HAVE A HIGH RESOLUTION MECHANISTIC UNDERSTANDING OF HOW NEF COUNTERACTS THE INHIBITORY INFLUENCE OF THE SERINC PROTEINS ON VIRAL INFECTIVITY, AND A MODEL FOR HOW THE ACTIVITY OF ENV IS INHIBITED BY THESE PROTEINS.
Interesting data from their 2020 990 filing
In the filing, the mission of the non-profit is noted as “Honoring military service with science; our bench-to-bedside approach has led to breakthroughs in areas such as shingles prevention, heart disease, metabolic diseases and ground breaking work on post-traumatic stress disorder.”.
When referring to its responsibilities, they were outlined as: “To enhance the health of veterans of all generations through research and education.”.
- The state in which the non-profit is legally registered to operate is CA, as per legal records.
- The filing documents the non-profit's address in 2020 as 3350 LA JOLLA VILLAGE DR BLDG 13, SAN DIEGO, CA, 92161.
- According to the non-profit's form, they have 194 employees on their payroll as of 2020.
- Is not a private foundation.
- Expenses are greater than $1,000,000.
- Revenue is greater than $1,000,000.
- Revenue less expenses is -$295,510.
- The organization has 13 independent voting members.
- The organization was formed in 1989.
- The organization pays $10,942,612 in salary, compensation, and benefits to its employees.
- The organization pays $0 in fundraising expenses.
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