Grace Science Foundation

Grace Science Foundation

San Francisco, CA 94103
Tax ID46-5727883

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About this organization






Our mission is to cure NGLY1 deficiency. We do this by pioneering approaches to scientific discovery that are faster, less expensive and more collaborative.


Stanford University (Bertozzi Lab) - Team began investigating a possible role for ferroptosis and oxidative stress in the pathologies associated with NGLY1 deficiency. These findings touch on known pathways and could therefore inform potential therapeutic strategies. Additionally, the team made significant progress on a fluorogenic probe to detect NGLY1 activity in live cells that does not require the cells to be genetically engineered. The team also developed a first version of NGLY1-TurboID, a system designed to identify NGLY1 interactors and potential substrates. This is critical to uncovering proteins involved in NGLY1 function as well as additional proteins, like NFE2L1, that NGLY1 may regulate through deglycosylation. Such proteins could serve as potential targets for a small compound therapeutic and could provide essential insight into NGLY1 biology.

Interesting data from their 2019 990 filing

According to the filing, the non-profit's mission is “The mission of the foundation is to support and fund the development of life-saving treatment for patients that are deficient in the n-glycanese enzyme and those suffering from related genetic diseases. the activities of the foundation will involve providing grant funding to hospitals and medical research facilities which are conducting medical research in various fields relating to the search for understanding and treatment of this condition, and fostering collaboration between academia, research institutions, hospitals, private companies, and governmental agencies.”.

When referring to its actions, they were described as: “The mission of the foundation is to support and fund the development of life-saving treatment for patients that are deficient in the n-glycanese enzyme and those suffering from related genetic diseases.”.

  • According to the law, the state of operation reported by the non-profit is CA.
  • As per the filing, the address of the non-profit for 2019 is 235 KANSAS STREET SUITE 200, SAN FRANCISCO, CA, 94103.
  • According to their form, the non-profit as of 2019 has a total of 0 employees.
  • Is not a private foundation.
  • Expenses are between $500,000 and $1,000,000+.
  • Revenue is greater than $1,000,000.
  • Revenue less expenses is $125,924.
  • The organization has 7 independent voting members.
  • The organization was formed in 2014.
  • The organization pays $0 in salary, compensation, and benefits to its employees.
  • The organization pays $0 in fundraising expenses.

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